NFL Week 6 Picks: Schedule, Odds, Trends And Predictions Against The Spread

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Quarterback Aaron Rodgers #12 of the Green Bay Packers

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Week 6 will mark the first time during the 2021 NFL season that every team won’t be suiting up. Four teams are out on bye—the first breaks during this expanded 17-game campaign—leaving Sunday looking a bit lighter than usual.

There are still plenty of can’t-miss matchups, starting on Thursday Night Football when Tom Brady and the defending champion Buccaneers visit the City of Brotherly Love for a showdown with the Eagles.

That primetime affair leads into an exciting Sunday slate that includes seven games simultaneously kicking off in the early afternoon. The Chargers vs. Ravens game headlines this time slot, a clash between two AFC powerhouse programs where the result could have significant postseason ramifications.

The late afternoon may only feature three contests, but most of the country will be watching when the Cowboys take a rare trip to Foxborough to meet with the Patriots. These franchises haven’t met often, but have engaged in some memorable battles when they do share the field. It looks like another is on tap in Week 6, with Mac Jones and the plucky Pats looking to get back to .500 by toppling Dak Prescott’s surging Dallas squad.

The Week 6 schedule comes to a close with two intriguing primetime matchups. The first will see the Seahawks visiting the Steelers for a Sunday Night Football game between two struggling but still dangerous squads. Fans won’t want to miss Monday Night Football this week, as the Titans are taking on the red-hot Bills in a showdown that will assuredly impact the playoff picture in the AFC.

While there are no shortage of contests to get excited about on the Week 6 schedule, fans always have the option of upping the ante by placing a wager down. Whether your team is out on bye and you are looking for a way to get more invested or you just want to get a piece of the action, it’s never fun to make a losing bet.

Get more informed by checking out the week’s top betting trends. You can also find predictions for some of Week 6’s marquee matchups below. Before getting to the picks, take a peek at the complete schedule, start times, TV channels, live stream sites and updated odds courtesy of FanDuel for every Week 6 game during the 2021 NFL season.

NFL Week 6 Schedule And Odds

Week 6 Byes: Atlanta Falcons, New Orleans Saints, New York Jets, San Francisco 49ers.

*The Jaguars vs. Dolphins game will take place at Tottenham Hotspur Stadium in London, England.

Thursday Night Football can live streamed via Amazon Prime AMZN , NFL.com and FOX Sports GO. Sunday Night Football will be live streamed via NBC Sports and Monday Night Football via WatchESPN.

NFL Week 6 Betting Trends and Predictions

League-Wide Trend to Note

Road underdogs have been a strong play during the 2021 NFL season. Leading up to Week 6, visitors getting points have gone 30-19 overall, a cover rate of over 60 percent. Road teams getting six points or fewer have been even better, going 22-8 ATS for a nearly 75 percent cover rate.

Vikings at Panthers

The Vikings have gone just 2-10 against the spread over their last 12 games. Minnesota has struggled to cover since last season, including losing against the number in back-to-back games leading up to Week 6. The team is a 1.5-point favorite in a clash with the Panthers on Sunday, but hasn’t covered as chalk since last November.

Pick: Panthers +1.5

Packers at Bears

The Packers are 21-5 SU and 19-7 ATS versus the Bears since Aaron Rodgers became the starting quarterback in 2008. Rodgers has tossed 55 touchdowns against 10 interceptions and has a 107.2 passer rating in the 24 games he started and finished versus this opponent.

Green Bay, off to a 4-1 ATS start in 2021, visits Soldier Field in Week 6 as a 4.5-point favorite. Chicago hasn’t covered against this opponent since the 2018 season and hasn’t beaten the number as a home underdog in this series in a half-decade.

Pick: Packers -4.5

Raiders at Broncos

The Raiders are 5-2 SU and 6-1 ATS over their last seven meetings with the Broncos. These AFC West rivals will meet on Sunday at Mile High, with Denver laying 3.5 points at home. It will be Vegas’ first game without Jon Gruden, who was let go from his head coaching post this week. It’s worth noting that the last five clubs to make a midseason coaching change have gone 4-1 SU in their first games following the appointment of a interim head coach.

Pick: Raiders +3.5

Texans at Colts

The Colts are 5-1 SU and ATS over their last six matchups with the Texans. Indianapolis’ only failure to cover since December 2018 occurred in the most recent meeting, where the Colts beat a 7.5-point underdog Houston team by a touchdown. Indy is once again a massive favorite for this AFC North rivalry game, opening as 9.5-point chalk in Week 6. Don’t expect many points to be scored here, as four of the last five and eight of the last 10 games involving these teams has gone under.

Pick: Colts -9.5

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